KMID : 1037520210370030029
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Vascular Specialist International 2021 Volume.37 No. 3 p.29 ~ p.29
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Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?
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Yucel Cihan
Ketenciler Serkan Tenekecigil Aslihan Kiziltan Feryaz Kayalar Nihan
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Abstract
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Purpose: The hypoxia inducible factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body¡¯s response to hypoxia. This study aimed to analyze the regulation of HIF-1¥á following vascular and/or endovascular surgery in peripheral arterial disease (PAD) patients.
Materials and Methods: A total of 40 patients with PAD (¡ÃRutherford category 3) were included in this prospective study. The mean age was 61.9¡¾9.2 years. Open surgery was performed in 16 patients, and endovascular intervention was performed in 34 patients. At preoperative (T1), postoperative day 1 (T2), and month 3 (T3), the serum HIF-1¥á levels were checked using the ELISA technique.
Results: At T3, the ankle-brachial index was significantly higher than the preoperative value (P<0.001). Serum HIF-1¥á levels at T1, T2, and T3 were 2.0¡¾1.7 ng/mL, 1.9¡¾1.7 ng/mL, and 1.6¡¾1.4 ng/mL, respectively. Serum HIF-1¥á levels between T1 and T3 and between T2 and T3 were significantly different (P<0.05). The preoperative HIF-1¥á levels were lowest in iliac lesions compared to femoropopliteal or tibial lesions.
Conclusion: The HIF-1¥á levels were decreased in all patients on postoperative days, T2 and T3, compared with the preoperative values. Our results indicated that HIF-1¥á may be a surrogate marker after revascularization in patients with PAD. Further studies are needed to analyze the sensitivity, specificity, and cut-off values of HIF-1¥á in patients with PAD.
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KEYWORD
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Hypoxia inducible factor 1¥á, Atherosclerosis, Peripheral arterial disease, Endovascular procedures, Reperfusion
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